Royal Air Force Typhoon fighter aircraft have conducted a mission with France's air force in a joint strike against an underground arms cache in Syrian territory employed by the IS group, as stated by the UK's MoD.
The location, pinpointed through intelligence, was thought to be housing weapons and explosive materials, the release indicated, and was positioned in mountainous terrain just to the north of the ancient city of Palmyra in Syria's central region.
"Our aircraft employed laser-guided Paveway IV weapons to hit a number of entry passages providing entry to the site... initial indications suggest the objective was successfully hit," the ministry announced.
There was no indication of any civilian casualties in the attack on Saturday evening and each participating jet made a safe return, the MoD added.
The British jets were supported by a Voyager refuelling tanker.
The Islamic State group - referred to as the so-called Islamic State - established jihadist rule over large swathes of Iraq and Syria prior to its 2019 collapse.
"This action shows British leadership, and commitment to work closely with our partners, to eradicate any revival of IS and their dangerous and violent ideologies in the area," Britain's Defence Chief John Healey said.
RAF aircraft have carried out overwatch operations over Syria to "deter any attempted comeback" of IS following its routing at the Baghuz confrontation in 2019, the ministry said.
"I must thank the personnel of the UK armed forces who took part in this strike for their expertise and their courage," the Defence Secretary said. "They were part of numerous British personnel stationed over the festive period. This operation, to take out terrorist threats who endanger our way of life, shows how our armed forces are always on standby, all year round, keeping Britain secure domestically and powerful internationally."
In December, the US military executed what it termed a "massive strike" targeting Islamic State objectives in the country, following an attack claimed the lives of two American soldiers and a civilian linguist in Palmyra.
The U.N. reports Islamic State still has roughly 5-7 thousand fighters in Iraq and Syria.